Bexarotene via CBP/p300 induces suppression of NF-kappaB-dependent cell growth and invasion in thyroid cancer
نویسندگان
چکیده
Abbreviations : ATRA, all-trans-retinoic acid ; DTC, differentiated thyroid cancer ; FTC, follicular thyroid carcinoma ; NIS, Na/I symporter ; NF-kappaB, nuclear factor kappaB; RA, retinoic acid ; RAR, retinoic acid receptor ; RARE, retinoic acid response element ; RXR, retinoid X receptor ; TG, thyroglobuline ; TPO, thyroid peroxydase ; TSHR, thyroid stimulating hormone receptor ; PAX8, paired box 8 ; PPARγ, peroxisome proliferator-activated receptor gamma ; PMA, phorbol myristate acetate ; 13-cis RA, 13-cis retinoic acid ; DIO1, type I iodothyronine 5’-deiodinase.
منابع مشابه
Bexarotene via CBP/p300 induces suppression of NF-κB-dependent cell growth and invasion in thyroid cancer.
PURPOSE Retinoic acid (RA) treatment has been used for redifferentiation of metastatic thyroid cancer with loss of radioiodine uptake. The aim of this study was to improve the understanding of RA resistance and investigate the role of bexarotene in thyroid cancer cells. EXPERIMENTAL DESIGN A model of thyroid cancer cell lines with differential response to RA was used to evaluate the biologica...
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